AB0709 CHARACTERIZATION OF NAILFOLD CAPILLAROSCOPY IN COVID-19: A CASE CONTROL STUDY

Background: Nailfold capillaroscopy is a relatively easy-to-access, low-cost clinical tool that could help identify early coagulopathy in subjects with SARS-CoV-2, but specific findings vs. controls and its possible prognostic role has not been studied. Objectives: To describe capillaroscopic their usefulness patients COVID-19 compared to healthy controls. Methods: We designed cross-sectional study, carried out single care center for critical SARS-CoV-2 pneumonia at the ABC Medical Center, Mexico City, which included from an intensive unit (ICU) internal medicine ward March April 2020. Demographic, biochemical features were collected. All signed informed consent study was approved by hospital ethics committee. underwent nail capillary imaging of 3 central fingers each hand portable microscope 60-100x magnification coupled smartphone 7 megapixel images immersion medium. Capillaroscopy performed who did have fever or hypothermia, need vasopressors time evaluation. Control are matched on age sex database without rheumatic diseases. Image evaluation blinded way characteristics. Prior analysis images, pilot test obtained 4 rheumatologists random cases, obtaining acceptable global agreement visualization capillaries alterations bed. (Kappa = 0.58, p 0.0019). Obtained data capillaroscopies used be between severe moderate cases pneumonia. Additionally, we against population order establish reference. Results: 27 32 similar demographic features. Patients had mean 43 +/- 13.8 years, 63% female. Comorbidities present 44.4% with: type II Diabetes Mellitus 18.5%, systemic arterial hypertension rheumatoid arthritis 3.7%. The length stay 13 7.1 days, 48.1% admitted ICU, 40.7% required invasive mechanical ventilation. In review remarkable hemosiderin deposits (33 vs 12.5%, p=0.05), less frequently observable (77 100%, p=0.005), any abnormality (25.9 6.3%, p=0.03). Of notice, tortuosities 19%, dilatation 9.5%, serpentine pattern 4.8%, bush 9.5% decreased density only 4.8% cases. No avascular areas neoformation observed. Finally, presence associated worse presentation risk factors COVID-19: Male 66.7 27.8%, (p 0.024); Admission ICU 77% 33% 0.029); BMI > 30 kg/m2 27.8% 0.053). And admission OR 7.0 (95% CI 1.098 - 44.6). significant associations found abnormalities morphology. Conclusion: one first reports nailfold compare Previous this regard suggests endothelial dysfunction microvascular complications such as micro hemorrhage thrombosis. Further studies may confirm these value outcomes patients. References: [1]Chen N, Zhou M, Dong X, et al. Epidemiological characteristics 99 2019 novel coronavirus Wuhan, China: descriptive study. Lancet. 2020;395:507–13. [2]Cutolo Cortes S. patterns Acta Reumatol Port. 2007 Jan-Mar;32(1):29-36. [3]Natalello G, De Luca Gigante L, disease 2019: Broadening spectrum involvement. Microvasc Res. 2021;133:104071. Disclosure Interests: None declared